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Wound Closure

Coated VICRYL® Plus Antibacterial (polyglactin 910) Suture

Overview

Coated VICRYL Plus Suture is indicated for use in general soft tissue approximation and/ or ligation, except for ophthalmic, cardiovascular and neurological tissues.

Coated VICRYL Plus Sutures provide multiple benefits

  • Predictable breaking strength retention (BSR) profile to provide support for 14 to 28 days while tissues heal
  • Shown in vitro to kill bacteria and inhibit bacterial colonization of the suture
  • Proprietary suture coating and polymer properties minimize drag force and elicit only a slight tissue reaction during absorption
Description & Specs

Coated VICRYL Plus Sutures offer benefits in a range of surgical applications, including

  • Predictable breaking strength retention (BSR) profile to provide support for 14 to 28 days while tissues heal
  • Provides protection against colonization of the suture by bacteria commonly associated with SSIs, including
    • Staphylococcus aureus
    • Staphylococcus epidermidis
    • Methicillin-resistant Staphylococcus aureus (MRSA)
    • Methicillin-resistant Staphylococcus epidermidis (MRSE)
  • Smooth tissue passage, exceptional handling, and knot security
    • Multifilament design provides greater pliability than monofilament sutures and unsurpassed knot security
    • Proprietary suture coating lowers tissue drag compared with standard braided sutures, and ensures easy knot sliding and knot positioning
    • Hydrolytic process elicits only a slight tissue reaction during absorption
Suture Construction Suture Color Available Sizes Suture BSR* Profile Absorption complete by:
Braided Violet / White (undyed) 5/0 through 2 2 weeks 75% 56-70 days
3 weeks 50%
4 weeks 25%

View the full portfolio of Coated VICRYL Plus Antibacterial Sutures on the Ethicon Product Catalog site

  • * BSR=breaking strength retention (tensile strength of suture in vivo)
Videos & Media

Simple Intrerrupted Closure Technique Video

Simple interrupted closure technique video.

Videos

Simple Intrerrupted Closure Technique Video


Simple interrupted closure technique video.

Traditional Suture Continuous Closure Technique Video


Traditional suture continuous closure technique video.

PDFs

There are no related PDFs for this product.
Science & Technology

Strength

Until wound tissues regain sufficient strength, the suture must provide the support the tissue requires to maintain its integrity.

Wound tissue load graph

Coated VICRYL Plus Sutures have a predictable breaking strength retention (BSR) profile to provide support for 14 to 28 days while tissues heal.

Coated VICRYL days post implantation graph

Protection

Risks for Surgical Site Infections (SSIs)

SSIs are caused by many factors –
some are controllable, others are uncontrollable179,185

Controllable
Uncontrollable
  • Endogenous bacteria179
  • Exogenous bacteria from:179
    • Surgical personnel
    • Surgical tools
    • OR environment
  • Bacterial colonization of the suture179,185
  • Patient Comorbidites179
    • Age
    • Diabetes
    • Smoking
    • Obesity
  • Prior contamination of the wound179

Wound closure provides an opportunity to address these controllable risks

Suture as a route of infection

Percutaneous sutures creates a conduit for bacteria172

  • Topical antiseptics can only address bacteria on the top few layers of the stratum corneum, not the bacteria hiding in the deeper layers of in the hair follicles172
    Before antiseptic application
    Immediately following antiseptic application
    MONOCRYL before after comparison
  • Until the epidermis heals (24-48 hours after surgery), bacteria can enter the wound from the patient’s skin or the environment117

Suture as a site for infection

Foreign materials, such as sutures, lower the number of bacteria required to cause an infection:179

  • Typical bacterial concentration required for SSI to develop: 105 CFU/g tissue179
  • Bacterial concentration required on implant for SSI to develop: 102 CFU/g tissue179

When implanted, sutures are rapidly coated with tissue protein, which creates sites for bacterial colonization:185,190,191

  • This colonization can lead to biofilm formation185
  • Biofilm formation increases the difficulty of treating an infection190

Evaluating antibacterial efficacy

PDS® Plus Antibacterial (polydioxanone) Suture inhibit bacterial colonization of the suture after direct challenge with bacteria

MRSA adheres to non-triclosan-treated suture (magnification 5,400X)
Only a few MRSA (arrows) adhere to triclosan-treated suture (magnification 5,260X)

As seen in the images below, bacteria (dark red) will grow in all areas of a petri dish except for the "zone of inhibition" on and around a Plus Antibacterial Suture.

"Before" – Prior to incubation
"After" – Zone of inhibition at 24 hrs
MONOCRYL before and after comparison

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