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Wound Closure

Plus Antibacterial Suture Portfolio

Plus Antibacterial Suture Portfolio

Plus Antibacterial Suture Portfolio

Overview

Plus Antibacterial Sutures: Solutions to address the risks you face today

Surgical site infections (SSIs) are caused by many factors – some are controllable, while others are uncontrollable. Suture selection provides an opportunity to address a known risk factor for infection – bacterial colonization of the suture.179,185

Percutaneous sutures create a conduit for bacteria to enter the wound. Additionally, like all foreign bodies, when implanted, sutures are rapidly coated with tissue protein, creating sites for bacterial colonization. This colonization can lead to biofilm formation, which can increase the difficulty of treating an infection even in the presence of antibiotics.185,190,191

Plus Antibacterial Solutions are the only commercially available sutures with antibacterial protection.

  • Proven in vitro to kill bacteria and inhibit bacterial colonization of the suture for 7 days or more137,138,146
  • Effective against pathogens commonly associated with surgical site infections, including:
    • Staphylococcus aureus
    • Staphylococcus epidermidis
    • Methicillin-resistant Staphylococcus aureus (MRSA)
    • Methicillin-resistant Staphylococcus epidermidis (MRSE)
    • Escherichia coli*
    • Klebsiella pneumoniae*

As seen in the images below, bacteria (dark red) will grow in all areas of a petri dish except for the “zone of inhibition” on and around a Plus Antibacterial Suture.

"Before" – Prior to incubation
"After" – Zone of inhibition at 24 hrs
MONOCRYL before and after comparison

A range of Plus Sutures are available to meet the needs of skin and fascial tissue repair, including MONOCRYL® Plus Antibacterial (poliglecaprone 25) Sutures and PDS® Plus Antibacterial (polydioxanone) Sutures.

Site References

  • * Applicable to MONOCRYL Plus Suture and PDS Plus Suture only
Description & Specs

A range of Plus Sutures are available to meet the needs of skin and fascial tissue repair, including MONOCRYL® Plus Antibacterial (poliglecaprone 25) Sutures and PDS® Plus Antibacterial (polydioxanone) Sutures.

MONOCRYL Plus Suture

Suture Construction Suture Color Available Sizes Suture BSR* Profile Absorption complete by:
Monofilament Violet / Clear (undyed) 6/0 through 1   Undyed (clear) Dyed (violet) 91-119 days
1 week 50-60% 60-70%
2 weeks 20-30% 30-40%

View the full portfolio of MONOCRYL Plus Antibacterial Sutures on the Ethicon Product Catalog site

PDS Plus Suture

Suture Construction Suture Color Available Sizes Suture BSR* Profile Absorption complete by:
Monofilament Violet / Clear (undyed) 6/0 through 1   3/0 and larger 4/0 and smaller 182-238 days
2 weeks 80% 60%
4 weeks 70% 40%
6 weeks 60% 35%

View the full portfolio of PDS Plus Antibacterial Sutures on the Ethicon Product Catalog site

Coated VICRYL® Plus Antibacterial (polyglactin 910) Suture

Suture Construction Suture Color Available Sizes Suture BSR* Profile Absorption complete by:
Braided Violet / White (undyed) 5/0 through 2 2 weeks 75% 56-70 days
3 weeks 50%
4 weeks 25%

View the full portfolio of Coated VICRYL Plus Antibacterial Sutures on the Ethicon Product Catalog site

  • * BSR=breaking strength retention (tensile strength of suture in vivo)
Science & Technology

Protection

Risks for Surgical Site Infections (SSIs)

SSIs are caused by many factors –
some are controllable, others are uncontrollable179,185

Controllable
Uncontrollable
  • Endogenous bacteria179
  • Exogenous bacteria from:179
    • Surgical personnel
    • Surgical tools
    • OR environment
  • Bacterial colonization of the suture179,185
  • Patient Comorbidites179
    • Age
    • Diabetes
    • Smoking
    • Obesity
  • Prior contamination of the wound179

Wound closure provides an opportunity to address these controllable risks

Suture as a route of infection

Percutaneous sutures create a conduit for bacteria189

  • Topical antiseptics can only address bacteria on the top few layers of the stratum corneum, not the bacteria hiding in the deeper layers of in the hair follicles189
    Before antiseptic application
    Immediately following antiseptic application
  • Until the epidermis heals (24-48 hours after surgery), bacteria can enter the wound from the patient's skin or the environment117

Suture as a site for infection

Foreign materials, such as sutures, lower the number of bacteria required to cause an infection179

  • Typical bacterial concentration required for SSI to develop: 105 CFU/g tissue179
  • Bacterial concentration required on implant for SSI to develop: 102 CFU/g tissue179

When implanted, sutures are rapidly coated with tissue protein, which creates sites for bacterial colonization185,190,191

  • This colonization can lead to biofilm formation185
  • Biofilm formation increases the difficulty of treating an infection190