Secure skin closure is an integral step of nearly every surgical procedure. If the closure device does not provide the strength and support required by the skin tissue, the wound edges may separate, providing a potential pathway for bacterial contamination, which can lead to infection, suboptimal cosmesis, and low patient satisfaction.^1,170,171

Longer incisions present unique clinical challenges, such as approximating wound edges evenly, distributing tension evenly across the wound, and maintaining the integrity of the surgical site.

DERMABOND™ PRINEO™ Skin Closure System is a unique two-part skin closure system consisting of:

• A 2-octyl cyanoacrylate topical skin adhesive for proven strength and microbial protection in vitro¹
• A flexible, self-adhesive polyester mesh for excellent approximation and healing¹

DERMABOND™ PRINEO™ can add strength and protection when closing medium to long incisions.

Strong:

• DERMABOND™ PRINEO™ can replace use of subcuticular sutures for skin closure.* It has tissue holding strength equivalent to 3-0 MONOCRYL™ (poliglecaprone 25) Sutures (shown ex-vivo)¹
• DERMABOND™ PRINEO™ was shown to provide statistically significant greater skin holding strength than skin staples or subcuticular suture^†

Protective:

• Provides a flexible microbial barrier with 99% protection in vitro for 72 hours against organisms commonly responsible for surgical site infections (SSIs)^117,‡
• DERMABOND™ PRINEO™ demonstrated in vitro inhibition of gram positive (MRSA and MRSE) and gram negative bacteria (E. coli)^§

Efficient:

• May reduce final layer of skin closure time up to 75%¹

DERMABOND™ PRINEO™ is part of the DERMABOND® Portfolio. Each product in the DERMABOND® portfolio provides strong, protective, and efficient closure.^{1,117,192,193}

The products in the DERMABOND® Portfolio are supported by more clinical evidence, outcomes data, and publications than any other Topical Skin Adhesive.¹

DERMABOND™ PRINEO™ Skin Closure System is an innovative, two-part system for uncompromised strength and healing.^1,202

Applicator and liquid adhesive

• A 2-octyl cyanoacrylate topical skin adhesive provides strength and microbial protection in vitro^1,202
• Sets in approximately 60 seconds when applied to mesh tape
• Before contacting the mesh tape, the adhesive has a 2-hour working time¹

Polyester mesh tape

• A flexible, self-adhesive polyester mesh tape in combination with the liquid adhesive provides excellent approximation and healing¹
• Contains an initiator to accelerate the polymerization of the liquid adhesive
• Each dispenser contains 60 cm of mesh tape

DERMABOND™ PRINEO™ enhances comfort and convenience for patients

• No need for post-surgical dressings may mean easier self-care
• If directed by the health care practitioner, patients are able to shower immediately following the procedure.
• Mesh tape removes easily when wound is sufficiently healed¹

DERMABOND™ PRINEO™ can be used as an alternative to subcuticular sutures when closing medium to long incisions¹

Secure skin closure is an integral step of nearly every surgical procedure. If the closure device does not provide the strength and support required by the skin tissue, the wound edges may separate, providing a potential pathway for bacterial contamination, which can lead to infection, suboptimal cosmesis, and low patient satisfaction.^1,170,171

Excellent outcomes can be achieved if a skin closure device:

• Provides the strength to maintain skin edges so that they remain approximated and level
• Distributes tension along the entire incision, adding uniform strength to the incision and preventing skin gaps from forming when the skin is stressed
• Creates a strong, flexible barrier to prevent bacteria from entering the incision until the epidermis has fully healed

Longer incisions present unique clinical challenges, such as approximating wound edges evenly, distributing tension evenly across the wound, and maintaining the integrity of the surgical site.

DERMABOND™ PRINEO™ Skin Closure System is a unique two-part system that consists of a liquid adhesive and a polyester mesh.

• The liquid adhesive contains a highly purified 2-octylcyanoacrylate monomer, which, after polymerization is stronger, more flexible, and less brittle than other cyanoacrylates.¹ Furthermore, the adhesive's formulation includes proprietary additives to enhance strength, flexibility, and adherence to the skin¹
• The polyester mesh facilitates wound edge approximation and contains a chemical initiator to ensure consistent, reliable polymerization times¹

The benefits of DERMABOND™ PRINEO™ are supported by pre-clinical and clinical data.¹

Strong

DERMABOND™ PRINEO™ was shown to provide statistically significant greater skin holding strength than skin staples or subcuticular suture.*

Protection

Provides a flexible protective barrier that:

• Conforms to the body’s contours and remains secure and in place¹
• Demonstrated in vitro inhibition of gram positive (MRSA and MRSE) and gram negative bacteria (E. coli)^†
• Proven 99% effective through 72 hours in vitro against bacteria commonly associated with surgical site infection, including:¹
  • Pseudomonas aeruginosa
  • Escherichia coli
  • Enterococcus faecium
  • Staphylococcus aureus
  • Staphylococcus epidermidis

Efficient

DERMABOND™ PRINEO™ may reduce final layer of skin closure time up to 75%¹

DERMABOND™ PRINEO™ was compared to subcuticular sutures in a randomized, controlled, multicenter trial of patients (n=83) undergoing abdominoplasty or body lift procedures requiring incisions ≥ 20cm. Patients were randomized for final closure on half the incision using sutures and the other half using DERMABOND™ PRINEO™.¹

Results:1
	DERMABOND™ PRINEO™	Subcuticular sutures	Statistical significance
Mean time for closure	1.46 min	6.65 min	P<0.0001

A significant reduction in final skin closure was also seen in a second clinical study (n=79) where breast incisions ≥ 15 cm were closed using either DERMABOND™ PRINEO™ or subcuticular sutures¹

Results:1
	DERMABOND™ PRINEO™	Subcuticular sutures	Statistical significance
Mean time for closure	2.56 min	16.22 min	P<0.0001

Cosmesis

DERMABOND™ PRINEO™ provides excellent cosmetic results comparable to sutures¹



15 days post-surgery

Cosmetic results similar to sutures at 90 days...²¹⁴

As rated on the modified Hollander Cosmesis Scale, there were no significant differences between DERMABOND™ PRINEO™ and sutures for any parameters evaluated, including:²¹⁴

• Step-off border
• Contour irregularities
• Wound margin separation
• Edge inversion
• Excessive inflammation
• Overall appearance

...and through the 1-year follow-up period²¹⁴

In patients followed for 1 year (n=50), there were no significant differences between DERMABOND™ PRINEO™ and sutures for any parameters at 90 days, 6 months, or 1 year²¹⁴

Site References

• * In an ex vivo study, more load in N was required to create 3 ± 1 mm gap between skin edges approximated with DERMABOND™ PRINEO™ Skin Closure System, than with subcuticular 3-0 MONOCRYL™ (poliglecaprone 25) Suture or PROXIMATE® Ethicon Endo Surgery skin staples (p=0.00)¹
• ^† Clinical significance is unknown¹