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Wound Closure

DERMABOND ADVANCED® Topical Skin Adhesive

Overview

Secure skin closure is an integral step of nearly every surgical procedure. If the closure device does not provide the strength and support required by the skin tissue, the wound edges may separate, providing a potential pathway for bacterial contamination, which can lead to infection, suboptimal cosmesis, and low patient satisfaction.1,170,171

DERMABOND ADVANCED Adhesive can add strength and protection to an incision.

  • Strength: When used in addition to sutures, DERMABOND ADVANCED Adhesive was shown ex vivo to add 75% more strength to wound closure than sutures alone1
  • Microbial barrier: DERMABOND ADVANCED Adhesive provides a microbial barrier with 99% protection in vitro for at least 72 hours against organisms commonly responsible for surgical site infections (SSIs)*,117,192
  • Inhibition of bacteria: DERMABOND ADVANCED Adhesive demonstrated in vitro inhibition of gram-positive bacteria (MRSA & MRSE) and gram-negative bacteria (E. coli)

A patented, thicker formula with a unique blend of plasticizers and an initiator for precise control

  • Plasticizers increase flexibility and 3-dimensional strength for secure wound closure and patient comfort213
  • Initiator enables consistent setting time across various conditions and skin types213

DERMABOND ADVANCED Adhesive is part of the DERMABOND® Portfolio. Each product in the DERMABOND Portfolio provides strong, protective, and efficient closure.1,117,192

The products in the DERMABOND Portfolio are supported by more clinical evidence, outcomes data, and publications than any other topical skin adhesive.193

DERMABOND Boxes

Site References

  • * Staphylococcus epidermidis, Staphylococcus aureus, Escherichia coli, Enterococcus faecium, Pseudomonas aeruginosa
  • Clinical significance is unknown
  • As compared to High Viscocity DERMABOND® Topical Skin Adhesive
Description & Specs

DERMABOND ADVANCED Adhesive is a skin closure device used to hold closed easily approximated skin edges of wounds from surgical incisions or laceration.

  • DERMABOND ADVANCED Adhesive has a patented, proprietary chemical formulation that has been shown to provide excellent strength and microbial protection versus other commercially available topical skin adhesives.1
  • Compared with many other topical skin adhesives, DERMABOND ADVANCED Adhesive provides enhancements such as single-layer application, reduced drying time, and an ergonomically designed applicator for improved handling during application.1
DERMABOND Advanced Info

DERMABOND ADVANCED Adhesive may be used in conjunction with but not in place of deep dermal stitches.

PRODUCT CODE DESCRIPTION ADHESIVE VOLUME EA/BX
DNX12 Unique formulation with an easy-to-use applicator for precise control for wide and fine line applications 0.7 mL 12
DNX6 Unique formulation with an easy-to-use applicator for precise control for wide and fine line applications 0.7 mL 6

Site References

  • * Compared to currently available DERMABOND ADVANCED™ Topical Skin Adhesion.
Videos & Media

Dermabond Advanced Technique Video

Dermabond Advanced application technique video.

Videos

Dermabond Advanced Technique Video


Dermabond Advanced application technique video.

PDFs

There are no related PDFs for this product.
Science & Technology

Secure skin closure is an integral step of nearly every surgical procedure. If the closure device does not provide the strength and support required by the skin tissue, the wound edges may separate, providing a potential pathway for bacterial contamination, which can lead to infection, suboptimal cosmesis, and low patient satisfaction.1,170,171

Excellent outcomes can be achieved if a skin closure device:

  • Provides the strength to maintain skin edges so that they remain approximated and level
  • Distributes tension along the entire incision, adding uniform strength to the incision and preventing skin gaps from forming when the skin is stressed
  • Creates a strong, flexible barrier to prevent bacteria from entering the incision until the epidermis has fully healed

DERMABOND ADVANCED Adhesive has a propriety formulation consisting of:

DERMABOND Venn Diagram
  • A highly purified 2-octylcyanoacrylate monomer, which, after polymerization is stronger, more flexible, and less brittle than other cyanoacrylates1
  • A chemical initiator in the applicator tip to ensure consistent, reliable polymerization times202
  • Formulation additives to enhance strength, flexibility, and adherence to the skin202

The unique and proprietary formulation of DERMABOND ADVANCED Adhesive helps protect patients by maintaining wound integrity.117,192 DERMABOND ADVANCED Adhesive is supported by more clinical evidence and real-world data than any competing product.193

Strength

Sutures alone

Skin strength alone
Skin gaps form at a force of 182 mmHg212

Sutures with DERMABOND ADVANCED Adhesive

Skin strength with adhesive
Maintains skin approximation at a force of 320 mmHg212

Microbial barrier

With 99% protection in vitro for at least 72 hours against organisms commonly responsible for SSIs*,1,117

DERMABOND ADVANCED Adhesive bacterial growth

24, 48, 72 hours following application of DERMABOND ADVANCED Adhesive

Bacteria growth at 24, 48, and 72 hours

Inhibition of bacteria

DERMABOND ADVANCED Adhesive demonstrated in vitro inhibition of gram-positive bacteria (MRSA and MRSE) and gram-negative bacteria (E coli)†,1

DERMABOND ADVANCED™ Adhesive contact time graph DERMABOND ADVANCED™ Adhesive bacterial growth

Hospitalization costs

In a retrospective analysis of over 155,000 C-sections,§

  • Hospitalization costs for the group in which DERMABOND® Topical Skin Adhesive was used were on average lower by $500205
  • Patients on whom DERMABOND Adhesive was used had lower nonprophylactic antibiotic usage after Day 4 compared to patients closed with sutures or staples205
Hospitalization bar graph

Length of hospitalization

In a retrospective study of 1,3000 CABG patients post-operative hospital days were significantly reduced from a median of 13 days to 9 days for patients in whom DERMABOND® Adhesive was used to close the skin.205

Site References

  • * Staphylococcus epidermidis, Staphylococcus aureus, Escherichia coli, Enterococcus faecium, Pseudomonas aeruginosa
  • Clinical significance is unknown1
  • DERMABOND ADVANCED Adhesive has been shown in head-to-head testing to be equivalent or superior to DERMABOND Adhesive in all major performance categories.
  • § Premier Perspective™ Comparative Database

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