Research & Evidence

At Ethicon, we are working with thought-leading surgeons, researchers and endocrinologists to understand the physiological changes that can occur after bariatric surgery in order to develop new, beneficial therapies for the many patients who suffer from obesity and metabolic diseases such as type 2 diabetes. We are proud to share the findings supported by Ethicon from the MARS Initiative, the STAMPEDE trial, and the sleeve gastrectomy consensus statement.

Comparison of Economic and Clinical Outcomes between Patients Undergoing Laparoscopic Bariatric Surgery with Powered vs. Manual Endoscopic Surgical Staplers

Outcomes data from the Premier Perspective® Hospital Database demonstrates the use of Echelon Flex™ Powered Staplers was associated with fewer bleeding complications*, shorter OR time and lower overall procedural costs in bariatric procedures when compared to the Medtronic EndoGIA™ and manual staplers in general. We invite you to read one of the largest retrospective studies on surgical stapling ever completed comparing outcomes of over 21,000 bariatric surgery patients.

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MARS (Metabolic Applied Research Strategy) Initiative

In collaboration with parent company Johnson & Johnson, Ethicon invested $30 million over 7 years, working with leading researchers at Massachusetts General Hospital and the University of Cincinnati to understand mechanisms underlying the significantly improved patient outcomes associated with bariatric and metabolic surgeries.

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STAMPEDE (Surgical Treatment And Medications Potentially Eradicate Diabetes Efficiently) Trial

Ethicon is the primary supporter of the STAMPEDE clinical trial, designed to compare intensive medical therapy with surgical treatment using gastric bypass or sleeve gastrectomy (combined with intensive medical therapy) as a means to improve glycemic control in obese patients with Type 2 diabetes.

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International Sleeve Gastrectomy Expert Panel Consensus Statement

To optimize surgical techniques to reduce leaks and other complications in the sleeve gastrectomy procedures, Ethicon actively supports the world’s most experienced bariatric surgeons, led by Dr. Raul Rosenthal, to develop a consensus statement that provides best practice guidelines based on experience of more than 12,000 cases.

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Request for proposal


We accept unsolicited requests from interested researchers for funding and/or products to support independent research activities. Our support of projects can include direct funding to cover all or a portion of study-related costs, product, and study design input.

To get started, download our proposal form kit file_download

Site References

  • * Use of Ethicon powered staplers was associated with fewer bleeding / transfusion complications (1.61%) compared to Medtronic non-powered staplers (3.05%) p=0.010, in laparoscopic Sleeve Gastrectomy and Roux-en-Y Gastric Bypass procedures. Based on retrospective analysis of 21,466 cases from the Premier Perspective® Hospital Database.
  • † Use of Ethicon powered staplers was associated with shorter OR time (133 minutes) compared to Medtronic non-powered staplers (154 minutes), p=0.011, in laparoscopic Sleeve Gastrectomy and Roux-en-Y Gastric Bypass procedures. Based on retrospective analysis of 20,428 cases from the Premier Perspective® Hospital Database.
  • ‡ Use of Ethicon powered staplers was associated with lower overall hospital costs ($12,261) compared to Medtronic non-powered staplers ($14,038), p=0.022, in laparoscopic Sleeve Gastrectomy and Roux-en-Y Gastric Bypass procedures. Based on retrospective analysis of 21,466 cases from the Premier Perspective® Hospital Database.
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