Research & Evidence

We accept unsolicited requests from interested researchers for funding and/or products to support independent research activities. Our support of projects can include direct funding to cover all or a portion of study‐related costs, product and study design input. To get started, download our proposal form kit file_download

Ethicon also has an active partnership with the largest hepato-biliary and surgical oncology societies around the world to advance surgical technique.

A prospective randomized controlled trial: comparison of two different methods of hepatectomy
Hanyong S, Wanyee L, Siyuan F, Hui L, Yuan Y, Chuan L, Weiping Z, Mengchao W.

HARMONIC Technology allowed for less intraoperative blood loss, fewer surgical complications and earlier recovery of liver function after liver resection in a prospective randomized controlled trial comparing Pringle Manuver (n=80) vs. liver resection with Harmonic scalpel (n=80).

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Fusion technique for liver transection with Kelly-clysis and harmonic technology
Jagannath P, Chhabra DG, Sutariya KR, Shah RC

HARMONIC FOCUS resulted in less blood loss and faster transection times compared to CUSA when used for liver transection based on prospective comparative study between fusion technique with HARMONIC FOCUS (n=18) vs. CUSA-bipolar (n=18).

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Comparison of harmonic scalpel versus conventional knot tying for transection of short hepatic veins at liver transplantation: prospective randomized study
Olmez A, Karabulut K, Aydin C, Kayaalp C, Yilmaz S.

This prospective randomized trial compared the use of HARMONIC technology vs. ligation for sealing hepatic vessels during liver resection surgery. The study concluded that use of the HARMONIC technology resulted in lower bleeding rates compared to ligation for sealing hepatic vessels ≤ 2mm.

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A phase III, randomized, controlled, superiority trial evaluating the fibrin pad versus standard of care in controlling parenchymal bleeding during elective hepatic surgery
Koea JB, Batiller J, Patel B, Shen J, Hammond J, Hart J, Fischer C, Garden OJ

This prospective randomized controlled trial evaluated the safety and effectiveness of a fibrin pad in controlling bleeding during elective hepatic resection. The study concluded that the fibrin pad is safe and effective when used as an adjunct to achieve hemostasis during hepatic surgery.

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Hepatocellular carcinoma: surgical perspectives beyond the Barcelona clinic liver cancer recommendations
Guglielmi A, Ruzzenente A, Conci S, Valdegamberi A, Vitali M, Bertuzzo F, De Angelis M, Mantovani G, Iacono C.

In this review article, the authors evaluated the role of surgery beyond the Barcelona Clinic Liver Cancer staging system recommendations. The authors conclude that improvements in surgical techniques and perioperative care have increased the pool of patients who would benefit from the curative surgical liver resection.

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Operative blood loss independently predicts recurrence and survival after resection of hepatocellular carcinoma
Katz SC, Shia J, Liau KH, Gonen M, Ruo L, Jarnagin WR, Fong Y, D'Angelica MI, Blumgart LH, Dematteo RP.

This study prospectively assessed the oncological outcomes in 192 hepatocellular carcinoma patients undergoing liver resection surgery. The authors concluded that increased intraoperative blood loss during liver resection is an independent prognostic factor for tumor recurrence and death.

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