DERMABONDšADVANCED Adhesive is a fast setting adhesive capable of adhering to most body tissue and many other materials, such as surgical gloves and stainless steel. Inadvertent contact with any body tissue, and any surfaces or equipment that are not disposable or that cannot be readily cleaned with a solvent such as acetone should be avoided. Polymerization of DERMABONDšADVANCED Adhesive may be accelerated by water or fluids containing alcohol. DERMABONDšADVANCED Adhesive should not be applied to wet wounds. DERMABONDšADVANCED Adhesive should not be applied to the eye. If contact with the eye occurs, flush the eye copiously with saline or water. If residual adhesive remains, apply topical ophthalmic ointment to help loosen the bond and contact an ophthalmologist. When closing facial wounds near the eye with DERMABONDšADVANCED Adhesive, position the patient so that any runoff of adhesive is away from the eye. The eye should be closed and protected with gauze. Prophylactic placement of petroleum jelly around the eye, to act as a mechanical barrier or dam, can be effective in preventing inadvertent flow of adhesive into the eye. DERMABONDšADVANCED Adhesive will not adhere to skin pre-coated with petroleum jelly. Therefore, avoid using petroleum jelly on any skin area where DERMABONDšADVANCED Adhesive is intended to adhere. Use of DERMABONDšADVANCED Adhesive near the eye has inadvertently caused some patients eyelids to be sealed shut. In some of these cases, general anesthesia and surgical removal has been required to open the eyelid. DERMABONDšADVANCED Adhesive should not be used below the skin because the polymerized material is not absorbed by tissue and can elicit a foreign body reaction. Avoid excessive pressure of the applicator tip against wound edges or surrounding skin. This can force the wound edges apart and allow adhesive into the wound. DERMABONDšADVANCED Adhesive should be applied with a light brushing motion of the applicator tip over easily approximated wound edges. DERMABONDšADVANCED Adhesive should not be used in areas of high skin tension or across areas in which tension may increase, such as knuckles, elbows, or knees, unless the joint will be immobilized during the skin healing period or unless skin tension has been removed by application of another wound closure device (e.g., sutures or skin staples) prior to application of DERMABONDšADVANCED Adhesive. As with all wounds, DERMABONDšADVANCED Adhesive treated wounds should be monitored for signs of infection. Wounds with signs of infection, such as erythema, edema, warmth, pain, and purulent exudate, should be evaluated and treated according to standard practice for infection. DERMABONDšADVANCED Adhesive should not be used on wound sites that will be subjected to repeated or prolonged moisture or friction. DERMABONDšADVANCED Adhesive should only be used after wounds have been thoroughly and adequately cleaned and debrided in accordance with standard surgical practice. DERMABONDšADVANCED Adhesive polymerizes through an exothermic reaction in which a small amount of heat is released. DERMABONDšADVANCED Adhesive is to be applied in one continuous layer. NOTE: Applying DERMABONDšADVANCED Adhesive in one continuous layer onto a dry wound will minimize the sensation of eat. Applying a second layer is not required or recommended. If a second layer of DERMABONDšADVANCED Adhesive is applied or if large droplets of liquid are not spread thinly, the patient may experience an increased sensation of heat or discomfort. NOTE: Excessive pressure of the applicator tip against the wound edges or surrounding skin can result in forcing the wound edges apart and allowing DERMABONDšADVANCED Adhesive into the wound. DERMABONDšADVANCED Adhesive within the wound could delay wound healing and/or result in adverse cosmetic outcome. DERMABONDšADVANCED Adhesive is packaged for single patient use. Discard remaining opened material after each wound closure procedure. Do not resterilize DERMABONDšADVANCED Adhesive. Do not place DERMABONDšADVANCED Adhesive in a procedure pack/tray that will be sterilized prior to use. Exposure of DERMABONDšADVANCED Adhesive, to excessive heat (as in autoclaves or ethylene oxide sterilization) or radiation (such as gamma or electron beam) will increase its viscosity and may render the product unusable. For complete product details, please see Instructions for Use.