DERMABOND ADVANCED Adhesive is a fast setting adhesive capable of adhering to most body tissue and many other materials, such as surgical gloves and stainless steel. Inadvertent contact with any body tissue, and any surfaces or equipment that are not disposable or that cannot be readily cleaned with a solvent such as acetone should be avoided. Polymerization of DERMABOND ADVANCED Adhesive may be accelerated by water or fluids containing alcohol. DERMABOND ADVANCED Adhesive should not be applied to wet wounds. DERMABOND ADVANCED Adhesive should not be applied to the eye. If contact with the eye occurs, flush the eye copiously with saline or water. If residual adhesive remains, apply topical ophthalmic ointment to help loosen the bond and contact an ophthalmologist. When closing facial wounds near the eye with DERMABOND ADVANCED Adhesive, position the patient so that any runoff of adhesive is away from the eye. The eye should be closed and protected with gauze. Prophylactic placement of petroleum jelly around the eye, to act as a mechanical barrier or dam, can be effective in preventing inadvertent flow of adhesive into the eye. DERMABOND ADVANCED Adhesive will not adhere to skin pre-coated with petroleum jelly. Therefore, avoid using petroleum jelly on any skin area where DERMABOND ADVANCED Adhesive is intended to adhere. Use of DERMABOND ADVANCED Adhesive near the eye has inadvertently caused some patients eyelids to be sealed shut. In some of these cases, general anesthesia and surgical removal has been required to open the eyelid. DERMABOND ADVANCED Adhesive should not be used below the skin because the polymerized material is not absorbed by tissue and can elicit a foreign body reaction. Avoid excessive pressure of the applicator tip against wound edges or surrounding skin. This can force the wound edges apart and allow adhesive into the wound. DERMABOND ADVANCED Adhesive should be applied with a light brushing motion of the applicator tip over easily approximated wound edges. DERMABOND ADVANCED Adhesive should not be used in areas of high skin tension or across areas in which tension may increase, such as knuckles, elbows, or knees, unless the joint will be immobilized during the skin healing period or unless skin tension has been removed by application of another wound closure device (e.g., sutures or skin staples) prior to application of DERMABOND ADVANCED Adhesive. As with all wounds, DERMABOND ADVANCED Adhesive treated wounds should be monitored for signs of infection. Wounds with signs of infection, such as erythema, edema, warmth, pain, and purulent exudate, should be evaluated and treated according to standard practice for infection. DERMABOND ADVANCED Adhesive should not be used on wound sites that will be subjected to repeated or prolonged moisture or friction. DERMABOND ADVANCED Adhesive should only be used after wounds have been thoroughly and adequately cleaned and debrided in accordance with standard surgical practice. DERMABOND ADVANCED Adhesive polymerizes through an exothermic reaction in which a small amount of heat is released. DERMABOND ADVANCED Adhesive is to be applied in one continuous layer. NOTE: Applying DERMABOND ADVANCED Adhesive in one continuous layer onto a dry wound will minimize the sensation of eat. Applying a second layer is not required or recommended. If a second layer of DERMABOND ADVANCED Adhesive is applied or if large droplets of liquid are not spread thinly, the patient may experience an increased sensation of heat or discomfort. NOTE: Excessive pressure of the applicator tip against the wound edges or surrounding skin can result in forcing the wound edges apart and allowing DERMABOND ADVANCED Adhesive into the wound. DERMABOND ADVANCED Adhesive within the wound could delay wound healing and/or result in adverse cosmetic outcome. DERMABOND ADVANCED Adhesive is packaged for single patient use. Discard remaining opened material after each wound closure procedure. Do not resterilize DERMABOND ADVANCED Adhesive. Do not place DERMABOND ADVANCED Adhesive in a procedure pack/tray that will be sterilized prior to use. Exposure of DERMABOND ADVANCED Adhesive, to excessive heat (as in autoclaves or ethylene oxide sterilization) or radiation (such as gamma or electron beam) will increase its viscosity and may render the product unusable. For complete product details, please see Instructions for Use.